Blood is an important biologic fluid with many multiple properties and functions. One main and distinctive function of blood is to transport oxygen to tissues. After hemorrhage, the loss of blood leads to a hypovolemic state, which if serious can cause tissue hypoperfusion, and decreased tissue oxygenation may lead to total organ failure. Hemoglobinbased oxygen carders are being emerged as resuscitative agents for the treatment of hemorrhagic shock. Several hemoglobin therapeutic agents have passed phase I safety hurdles and are currently in phase lI and III of clinical trails.
