Stroke is a well-known leading cause of death and disability in the world. Cognitive and affective disorders are considered as frequent consequences within the first months after acute ischemic stroke. Cognitive decline is associated with poor outcomes, prolonged in-hospital stay and higher mortality rate in stroke survivors. Cognitive impairments can lead to behavioural changes that negatively impact patient’s adherence to physical rehabilitation. Anxiety and depression are also common complications among subjects with stroke. Affective disorders are associated with higher mortality rate, poor functional activity, and decreased quality of life in stroke survivors. However, recent research is focusing on post-stroke depression, not on anxiety. Impact of cognitive and affective disorders on outcome of stroke physical rehabilitation is still not established. Therefore, we aimed to assess cognitive and physical functioning, anxiety, and depression in post-stroke patients within in-hospital rehabilitation.