Cancer kills around a quarter of the people in the developed countries. Even when there is a screening test for a specific disease, most malignancies present with symptoms to basic care. However, cancer signs might also be indicators of a benign disease, therefore the GP must determine whether cancer is a possibility. Until recently, very little research had been done on this mechanism. The process of primary care diagnosis, particularly the selection of patients for quick inquiry, is examined in this review paper. It focuses on the four most prevalent malignancies in the United Kingdom: breast, lung, colon, and prostate, as they have been the topic of the most recent research.