Coagulation/fibrinolsis diseases are linked to Traumatic Brain Injury (TBI). We looked back on I instances that were taken to the hospital within an hour of the incident. On arrival and 3, 6, and 12 hours, 1 day, 3 days, and 7 days after injury, levels of hrombin-Antithrombin III comple A, D-dimer, and plasminogen activator inhibitor- AI- were assessed. The identification of predictive variables for coagulation and fibrinolsis was done using multivariate logistic regression analsis. Plasma A levels rose during admission and didnt start to decline until one da following the injury. Plasma D-dimer levels rose, reaching a maimum up to three hours after inur and then dropping off up to three days later. Plasma AI- levels rose up to hours after injury, then continued to rise until hours later, before declining until das later. In cases with poor outcomes, A, D-dimer, and AI- levels were higher during the acute period of TBI. D-dimer elevation from admission to hours after inur and AI- elevation from hours to da following inur were both significant negative prognostic markers, according to multivariate logistic regression analsis. Following a TBI, fibrinolsis, fibrinolsis shutdown, and hpercoagulation all began to occur simultaneously. Poor outcome was linked to hperfibrinolsis immediatel following inur and subseuent fibrinolsis shutdown.
