Amenorrhea, increased gonadotrophin levels, and hypoestrogenism are symptoms of Premature Ovarian Failure (POF) in women under the age of 40. Due to improved survival after cancer therapy, it is becoming more common and hassignificant physical and psychological repercussions. Despite this, the illness is still not well understood. Here, we examine the presentation and examination of POF, talk about recent developments in the treatment of affected women, and make recommendations for how to expand our understanding of the disorder. One percent of women experience Premature Ovarian Failure (POF), which results in hypergonadotrophic hypogonadism. Most of the time, the root cause goes undiscovered. The recognised reasons include: Genetic anomalies, which may include X chromosome or autosome abnormalities. Numerous genes have been investigated as potential POF causing candidates; however few have been shown to have obvious causal alterations. The found correlation between POF andother autoimmune diseases pointsto autoimmune ovarian damage. Numerous investigations have found anti- ovarian antibodies in POF, although their specificity and potential for pathogenesis are under debate. Iatrogenic after surgery, radiotherapy, or chemotherapy treatments, as in cancers.
